Any advice on which route from Lauterbrunnen to Como?
caforman, Sustenpass is in the wrong direction. See zoomable road map here: https://s.geo.admin.ch/6648ea1145
From Lauterbrunnen / Interlaken area your options are:
1) Grimselpass (2164 metres above see level) + Nufenenpass (2478 metres), then downhill all the way to Como.
2) Grimselpass + Furkapass (2429 m) + Gotthardpass (2106 m), then downhill.
3) Sustenpass (2164m) is heading east, into the valley up to the Gotthardpass. You then have a choice to go on the Autobahn through the Gotthard tunnel (boring), or over the top via the Gotthardpass.
But ultimately it is your choice which pass or passes you want to drive over.