Interlaken /Lucerne to Venice Journey

I have taken a ride on Flixbus (Munich to Salzburg in 2 hours) it seems very safe;
but I do not think I will ever again sit on a bus for 7 hours while on vacation(been there done that before). The one thing you have to pay attention to is just your belongings when the bus stops. I would probably take the train with all the changes or train to Basel and Fly direct. I don't like long train rides because you have to watch your belonging with all the stops.

Preferred method is train, though flying could be a little bit faster, at the cost of a lot more stress.

• Train involves a different route south from Interlaken or Luzern. but in both cases you get to go through the Alps, then change at Milan for Venice.
• This would be the best option for kids, they have room to move, spread out, eat and drink (and go to the toilet) with no restrictions.
• Fly would involve a train to Zürich airport (70 mins from Luzern, 2 hours from Interlaken), check in, airport hassle etc., and getting from the airport into Venice.
• Train is (nearly) door to door. Changing trains is not any problem.
• No way would I consider a bus all that way, especially overnight and doubly not with kids.

Lots of info about the trains here, including photos and a video: https://www.seat61.com/trains-and-routes/etr610.htm
When you reserve, try and get 4 seats round a table, then you have a private family space.

You are going to have to travel by train to Luzern anyway to get the Flixbus to Venice. From Luzern, you can get to Venice with a single change in Milan in 6 1/2 hours. Train will be way more comfortable than sitting in a bus seat for 7+ hours overnight. I am not nearly as paranoid about luggage as the previous poster. Each of the 2 legs has 6 stops each, for just 2 to 4 minutes. And you have 5 sets of eyes.

I wouldn't be particularly paranoid about luggage on a train either. If anything I'd actually be more concerned on a bus where unloading happens out of sight...

As for connections from Interlaken to Venice I've found that there are three train connections with only two changes. The earliest (8:00 departure) has the changes in Switzerland (15' in Spiez and 30' in Brig). This should be more than ample even with kids.

The reclining seat on an overnight bus, even a nice new one like this, is no better than trying to sleep in an airplane seat.

Thanks for all the suggestions

We took the following route from Murren to Venice last year and loved it: Drive (or train) to Chur. Bernina Express to Tirano, Italy. Trenord regional train along Lake Como to Milan. Frecciargento fast train to Venice. Its a full day, leaving Chur at 8:30 am and getting into Venice about 8:00 pm, but the scenery of the Alps and Lake Como was worth it.

Look into flights from Zurich. Spend money to save time when on vacation!