How bout a nightlife? Club scene?

The only one of these towns I've strolled through at night was Interlaken, and the nightlife seemed to consist of a casino and a Hooters restaurant. If you're traveling in the winter, though, there may be more activity there and in some of the nearby ski resort towns, particularly Wengen and Grindelwald (think aprés ski).

I can't say for certain but my best guess would be Zurich and Milan would have the best nightlife/clubs. Definitely not Interlaken.

Lausanne (I reckon, not on your list) is alright. Zurich too. Zofingen, Lucerne, Bern, and Interlaken are not very exciting at night.

There must be a joke somewhere about a banker and a cowherd walking into a bar...