Seville to Lisbon or Madrid to Lisbon

The easiest way to determine this is to plug it into a flight search using your specific dates. Bus will be cheaper but you have to weigh time v money.
If you have time to spare an overnight, I noticed the bus stops in Merida, which has amazing Roman ruins. That would save you from a long bus ride and be well worth a stop!

Check flights. Crossing from Spain to Portugal is not as easy as it is with other countries.

Distances in Spain are a little deceiving.

I'd fly on Ryanair, EasyJet or Air Europa from Madrid to Lisbon. Sevilla is quite a bit to the west of Madrid.

From Madrid to Lisbon you will almost surely want to fly. You can also fly from Sevilla but should consider either bus or bus/train combination. rome2rio.com might be helpful in comparing the options.

Thank you all for the information!

Let us know what you decide--good luck!

We are doing the 14 day Spain in Late May. Considering flying into Barcelona but out of Sevilla with a 4 day stopover in Lisbon before returning to US. TAP airlines gives a free stopover in either Lisbon or Porto so that might be of interest to you. Prices are much higher than I expected so the free stop over with an hour flight between Sevilla and Lisbon seemed like a great opportunity.

A few more detail would help.
Where are you landing?
What other cities are you seeing?
How many days are we talking about?

Last October we did Madirid-Granada-Sevilla and flew to Lisbon from Sevilla.

We plan to fly into Barcelona. Then visit the usual tourist destinations such as Madrid, Granada, Toledo and Sevilla, etc.

My wife and I bought a ticket from Alsa from Lisbon to Sevilla in October 2022. It cost $25.50 for each of us. (Maybe we got a discount as we are in our 60s).
We left Lisbon Sete Rios station on a nice, mostly empty, coach bus operated by the Portuguese bus company Rede Expressos, which we used for several intercity bus rides. Departure was 10:30. Arrival Faro 13:45. Transfer buses. Scheduled 14:00 departure from Faro to Sevilla was a little late. Arrival in Seville at the centrally located Plaza de Armas bus station was 18:00, so about a 3 hour ride with a break and the time change (add an hour going east to Spain). We enjoyed seeing the landscape.
I highly recommend the night tour at the Alhambra’s Nazaries Palace in addition to a day visit.
We had 44 nights in Spain and Portugal.
Also I recommend at least 4 nights in Seville.
We rented a car when leaving Seville for Arcos (stayed in the Rick Steves room at Hotel El Convento-stunning) Ronda, Priego area, day trip to Las Alpujarras then car drop in Granada. Bus to Córdoba. High speed train to Barcelona.
Sorry. I should have written all this, and more, in a trip report.

Hi Matt, thank you for the information. You recommended 4 nights in Sevilla. Can you share your itinerary in Sevilla if you do not mind? Thanks!

I took the train from Madrid to Lisbon, not sure there is one now, but I remember that going from Seville to Lisbon there was no good rail connection.

Also, renting a car is bad, since there is a huge drop charge for dropping in another country.

My opinion is that you can do all the Spain trips by train.
Maybe Barcelona - Toledo - Madrid - Granada - Sevilla by train and then fly to Lisbon.
We did the Madrid - Granada - Sevilla - fly to Lisbon in October and it worked fine.
Go to Toledo before Madrid since all trains to Granada from Toledo go through Madrid.
You can do a day trip from Sevilla to Cordoba.
Enjoy!

Hoken, people on the Travel Forum have recommended 3 full days or more for Seville, and I’m glad we made the time for that. If one is short on time, two full days will have to do, but Sevilla’s charms are best enjoyed at a leisurely pace. We stayed in the mostly pedestrian zone of Barrio Santa Cruz at a comfortable AirBNB with a pleasant courtyard. It was real close to the Museo de Flamenco. The first evening we walked to the cathedral and stopped at Bodega Morales for tapas and beverages. Others here have posted about James Blick’s YouTube channel with his bar and restaurant tips and tours that he and his Spanish wife, Loli, post. He likely has videos of many Spanish cities’ bars and restaurants (and Lisbon, too).
Full Day 1- Cathedral and Giralda tour, probably did some of Rick’s Walk. Visited some bars. Bodeguita Antonio Romero has tasty food and lines to get seats. Day 2 Visited Tirana and sites (market, museum, Bar Santa Ana is fun local bar). Afternoon visit of the Flamenco Museum. Returned for the great early Flamenco show there. Day 3- Alcazar Tour, Archivo de Indios is stunning building and worth the free, short visit. There isn’t much to see. Finished Rick’s Walk. Bar Giralda is in an old building that, I think, had housed a Moorish bath. Walk to Plaza de Espana. The Alcazar ticket includes more sites but some were closed for renovation, We did walk up to see the Roman ruins at the Antiquarium and stumbled upon a free bluegrass concert by talented Spanish musicians there. One could visit the main sites in two full days. There were several other sites that Rick lists that we didn’t visit. The next days we got a taxi and drove to Jerez, Cadiz, Arcos. Into the mountains between Arcos and Ronda. Visited the dolmens of Antequera, a Museo de Anis and the next door anise distillery in Rute en route to Casa Oleo, which some folks here recommended. It’s a highly reviewed B&B in olive groves near Priego and the Subbetica National Park.
Another tip is Restaurante La Sanabresa in Madrid that I learned of here. In September 2022 we enjoyed a menus del dia (3 courses) at the price of 14 euros each which included a bottle of wine. It was so good we returned a couple days later and noticed a New York Times article (circa 2007) that mentioned the restaurant framed on the wall. There is a mix of Madrileños and just a few tourists.