Ryanair or Air Europa to Madrid from Rome?

Hi, I need to take a late evening flight from Rome to Madrid in June. Both Ryanair and Air Europa offer a flight. Ryanair is cheaper, but I do know there will be added fees. I wanted to know if anyone had an opinion on which airline for this flight. This flight is almost 3 hours long. I did notice that the airlines fly out of different airports in Rome Ryanair is Ciampino and Air Europa is Fuimicino. I did not know if this made a difference or not.
Thank you in advance for any replies!