We have stayed at the Preciados twice, and loved it. It's interesting that you are going to Granada but not staying in Ronda or a less-touristed town in that area. I personally don't go to Europe for a seashore visit, but Conil looks attractive. I am not certain I would change hotels an extra time to stay in Toledo, while I would want to visit, certainly. I'm suggesting that six hotels are a lot for ... exactly how many "nights on the ground?"
Are you renting a car? Seville: I don't know the Rey Alphonso X, but it seems below my usual budget level. There's another, more luxury hotel with a similar name. Alphonso X seems to be near the Hotel Las Casas de la Judería, which we used in 2005. It was an attractive old mansion, but a little tired. Air conditioning was important to us on that summer trip.