Hello, I assume you are aware you will be in Andalucia during the Semana Santa Holiday? There's nothing like it in the world, bigger than Christmas in that corner of Spain. It will certainly make your travel experience so much deeper and rewarding than any normal week. All the cities, towns and villages will have their own processions and celebrations combining music, art, and color.
Especially in places like Córdoba, Granada, Malaga, and Sevilla will have the most spectacular and intense Semana Santa processions that go well into the night and into the small hours of the morning. This year it goes from April 5th up until Easter Monday (public holiday) on the 13th this year.
If one goes to Andalucia during Semana Santa, for the main purpose of enjoying the processions and taking part in the general festivities you will be fine. However if you plan to just do the regular tourist things during Semana Santa, you may find a bit of a difficult time, due to reduced opening times/higher prices.
The Semana Santa revelers won't be especially going to see the Alhambra etc., if that is a concern, so you don't have to worry about extra crowds actually at the tourist sties, just everywhere in between. You can expect inflated hotel prices, sold out trains, and the potential for closed sites during Semana Sanata
However, you can do both, enjoy the processions and see the sights, though know you might not see everything on your list, but for an opportunity to see such a passionate manifestation of the local culture that is Semana Santa, I think it is well worth it. The trick is to do a lot of planning ahead of time and make sure to pre-purchase tickets and reserve hotels well ahead of time (like now! lol).
PS: Madrid is not so affected by the Semana Santa holiday.