After three years of booking and cancelling due to COVID and other life evets we are now planning to go in April of 2023. I propose this basic itinerary and would appreciate your comments. (Last trip we went to Madrid, Malaga, Granada, Ronda, Estepona and Marbella)
Fly into Madrid and immediately Renfe to Sevilla (ears can't take two flights in one day)
Two full days in Sevilla
Travel (probably by car) to Jerez for the day and then on to Cadiz that night
Two full days in Cadiz
Travel to Carmona and tour for one day, overnight in Carmona
Travel to Cordoba and tour one day, overnight in Cordoba
Travel back to Madrid (Renfe) and two full days there
Flight back home from Madrid
I realize that I'm backtracking a bit going to Madrid rather than an open jaw flight but I had to use some Iberia vouchers and that round trip was the best deal.