Going to Spain in November is a GREAT idea. Madrid, Barcelona and Andalucia are all chock-full of history, architecture and great food. Andalucia is a bit harder to reach and it's a large geographical area, so you'd be using more time traveling. "8 days off" sounds to me like you have 7 nights in Spain. That's not much to see Andalucia.
First, can you fly nonstop to Madrid and Barcelona? if so, I'd stick with them. If you have to connect anyway, maybe you can find single-connection routes into and out of Andalucia. There are small airports in Sevilla and Granada, but Malaga is significantly larger, so you're more likely to find flights there. If you fly into Madrid, it's at least 3 hours by train with one train change to Cordoba and nearly an hour more to Sevilla . That alone eats up a good chunk of your first day.
Andalucia has wonderful Moorish architecture, Madrid's more 18th-19th century, and Barcelona has tons of moderisme (akin to art nouveau), as well as a Gothic cathedral and several churches built in the centuries between them. Barcelona's history goes back to Roman times. Andalucia has some vestiges from Roman rule, but its gems are medieval, including a very well preserved Juderia in Cordoba and of course the Alhambra and the Mezquita.
If you only have 7 nights, consider spending it all in Barcelona. You can day trip to Girona to explore its medieval center, day trip to Tarragona for some Roman ruins (and a scenic rail journey along the coast). See the official TI site for all the possibilities.