Andalusia

This question, combined with your other question on Rome, leads me to believe that you have not purchased any guidebooks nor done any online research. You should first buy some books, do a bit of googling and then come back with a list of things that appeal to you and input will be provided.

Totally agree you need to self start with research.
Why are you considering driving.
Four days to see Andalusia is a misconception of what should be done. At best you could do two days in seville and then two days in granada.

Are you renting a car specifically for Andalucía, or will you already have one? If the former, reconsider. None of those cities are car friendly and all can easily be reached via train or bus (Granada is better by bus from Sevilla).

In four days (hopefully five nights):

Two nights (one full day) in Granada. Focus on the Alhambra for most of the day (get reservations in advance). In the evening, walk up the Albaycin to see the view of the Alhambra at sunset and take in a Sambra performance in one of the cave homes.

Drive to Ronda for a look around and a night. If you don't have the night, visit Ronda briefly, then drive to Seville. In Seville, focus on the Cathedral, Alcazar and surrounding quarter. You can also walk to the river to see the Golden Tower and Casa de Toro (bullring). In the evening, you can see a Flamenco performance and/or a bullfight if there is one when you're there.

Spend one night in Cordoba. Focus on the Mesquita and surrounding quarter here.

There is so much more to see. In four days, however, this will included the major sights about as efficiently as possible.

Brad has given you a good start. You can see videos and general descriptions of these towns at http://www.ricksteves.com/europe/spain/andalucia, but the practical, day-to-day travel details that you need are in guidebooks, such as Rick's. The Snapshot version would be enough if you're not visiting more of Spain.