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Travel itinerary suggestions. Portugal/Spain

We are flying into Porto September 17 early am. Leaving Madrid on the 26 th early am. Would like to stop in Fatima for a few hours. Want to see Seville and end up in Madrid. Lisbon is a possibility too .
Any suggestions on how much time to spend and order of cities?

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I wouldn’t spend more than two nights in Porto and that allows enough time to visit the Douro Valley if you’re interested. If not, spend one night in Porto then take a direct (no transfer) bus from Porto’s Campanhā station to Fátima’s Terminal Rodoviario station (2h 15m). You can then catch a bus from Fátima’s Terminal Rodoviario station to the Lisboa, Terminal Rodoviário de Sete Rios station (1h 30m).
From Lisbon take a direct flight to Sevilla and from Sevilla take a direct train to Madrid. If going from Sevilla to Madrid’s airport a transfer is required.