The major challenge that I see (as a Seattle resident) is getting back from parts of Europe in no more than one day.
Our corner of the country does have a smattering of nonstop flights to/from Europe. But, depending on where you begin the trip home, you may find the connections require you to overnight somewhere on the way (which is a deal-breaker for me).
If you are returning to Seattle from a major airline hub city that has nonstop flights to SEA (eg London, Paris, Frankfurt, Munich, and a few more), then you can get home in just one day. But if you begin your homeward flights from a smaller market airport, and especially if you are starting from central or eastern Europe, you may run into trouble - if it takes you a few hours to fly to (and connect through) one of the major European hubs, you may not get there early enough in the day to catch the nonstop to Seattle, and you may end up either needing to spend another night there, or you may have to fly to some city in North America - but if you have to connect in Toronto, Boston, New York, Philadelphia, Atlanta, Chicago, Dallas, San Francisco or Los Angeles, you may arrive there too late to catch the last flight of the day to Seattle (forcing an overnight there).
Finding a way to get all the way home to Seattle in no more than one day can be surprisingly difficult - I like to travel to smaller places (recent examples include Corsica, Malta, etc.; upcoming examples include southern Italy, Greece, etc,). I often have to do a "positioning flight" to/near a major hub a few days before, or else I have to spend two days getting home (this is not an entirely bad thing - I get to add on some random, unrelated city or region at the end of my trip, so I can get home in one day...). It's one of the disadvantages of living in the far northwest corner of the US Airline systems. As a consolation, we are well-positioned for flights to Asia, so there's that.
It's tempting to leave the flight home as an afterthought to your trip plan (you figure: "go to the airport, fly home" but it quickly gets more complicated than that). For me, I figure out how to get home before I book my outbound flights. I start by looking at the airports that have nonstops to Seattle that leave relatively late in the day (there are only a handful of those). As suggested above, take a look at Munich (and Frankfurt), which have a lot of flights to SEA. Surprisingly, I have found Istanbul also works well (Turkish Airlines has afternoon departures nonstop to SEA that we like to take).
YMMV. Just part of living in the upper left corner as we do.