Long weekend in AMS with teens - accom/food/sights?

We enjoyed a short stay in Amsterdam a few years ago, in late summer. We stayed with friends, somI cannot suggest a hotel, but we did like their neighborhood, known as De Pijp. There were lots of shops and restaurants, but maybe no hotels as it is more residential.

We walked everywhere. Our main goals were the botanical garden and Anne Frank Huis. Our friends went with us to the garden, as they had not been there before, and they were very impressed. Lunch in the Orangery café was excellent.

https://www.dehortus.nl/en/

In January the outside areas might be less interesting, but the greenhouses should be very nice.

Maybe a night out for Rijsttafel would be fun?

How many days do you actually have? When do you arrive? When will you depart? Where from, will you be jetlagged?
You have already some big sights planned, so depending how many days you’re actually here, you may not have a lot of time to do much else. The Vermeer exhibit doesn’t start until February 10, so unfortunately you’re here too early for that.
You may still be able to see the Amsterdam Light festival though https://amsterdamlightfestival.com/nl
The Adam Lookout may be a fun activity; https://www.adamlookout.com/

Adding some context - we will have 3.5 days on the ground and will not be jet lagged!

I will second Lola's rec for de Pijp - I stayed at an AirBnb in the de Pijp neighborhood and loved it! There are tons of locals who live here and lots of activity, and so many restaurants and cafes. Lots of places with Middle Eastern food, which I love. It has great public transportation (I was only a block away from a tram that took me to all the major sights in minutes) and beautiful Sarphatipark was right across the street. A must see is the Albert Cuyp Market, a large market in de Pijp. There was always something going on, and I think teens would love it. https://www.iamsterdam.com/en/explore/neighbourhoods/de-pijp

This might be fun for your kids: https://www.thisisholland.com/en/

Unfortunately the Vermeer exhibition doesn’t open until Feb 10 so if you are there in January it’ll be slightly early.

https://www.rijksmuseum.nl/en/tickets/articles

The national maritime museum is interesting and the De Gooyer windmill is close by.

https://www.hetscheepvaartmuseum.com/

You could also rent bikes near Centraal Station, cross the river on the pedestrian/bike ferry about 100 yards away, and spend a relaxing day exploring the very pretty poulder countryside north of the city on some of the dedicated bike trails there. The rides are pretty easy, and if you're ambitious the route up thru the Waterland area to the old eel fishing village of Marken is worth doing. The village has many places to have lunch or, alternatively, pick up the makings for a picnic anywhere along the Ijmeer.
Would be a very "Dutch" thing to do.

We did a food tour in the Jordaan that we really enjoyed. Genever was served one place but they would have non-alcoholic options as well.