JT-we visited Amsterdam this past summer and stayed at Wiechmann Hotel (see link below) and found it quite comfortable. It is on a busy canal, but we never heard the noise. As with most hotels in Amsterdam, it is tall and narrow, with no elevator. Expect steep stairs, but also expect a wonderful breakfast, gorgeous room with charm, and excellent staff. I believe it's in the Rick Steves Guidebook (happy coincidence on my part). It's centrally located and easily walkable to the Anne Frank Museum (one direction) and the Van Gogh/Rijksmuseum area (other direction).
At the time we were there, the Anne Frank house was only accepting online tickets, and maybe that has changed now, but I would highly recommend booking ahead of time. Expect to take 1-2 hours in the museum. It's fairly self-guided, so really depends on how long you linger over the diaries.
If you have time, consider visiting Rotterdam to the south-excellent architecture and the jumping off point for Kinderdijk Windmills, which is absolutely gorgeous. If that's not in your plans, then Zaanse Schans windmills is an hour just north of Amsterdam.