2 yrs ago husband and I did Venice, Florence, Orvieto and Rome. Our first time in Europe and we LOVED Italy! We are returning in April flying into Rome and plan to spend 4 nights in Rome, then we have 10 more nights. Itinerary suggestions? Tuscany towns?, Puglia?, Sicily? Help! Not opposed to renting a car somewhere but am worried it could be too stressful with the ZTLs. Also I have knee issues and worry about that.
Our favorite base has been Bologna. Excellent culture, best food in the world, and easy day trips to Modeno, Parma, Ravenna, Padua, and others. There are frequent fast trains from Rome to Bologna, as Bologna is a railway hub.
The car thing is no big deal, but it may not be worth worrying about if you choose an itinerary easy by train, such as Emilia-Romagna, Liguria, Naples and Amalfi. I found Puglia easier with a car but it’s not a requirement like it is in some areas (rural Tuscany). Try flipping through some guide books to see what appeals to you.