What's new in Rome that we shouldn't miss?

The Domus Aurea (open only on week-ends) and the first Exhibition of the Torlonia Marbles in 40 years. Advance reservations are required.

I also think that the Quirinale Palace was more difficult to visit 10 years ago, but I'm not sure.

There may be COVID-related changes in ticket procedures for some long-standing sights, possibly a need to get tickets in advance where one used to be able to just walk up. I'd definitely check the websites of all the places I knew I wanted to go.

Not exactly new but not all that well known. On our RS Rome tour this was suggested by Sarah Murdoch. Turned out to be one of the highlights of our trip. Book the English tour! https://www.palazzovalentini.it/domus-romane/index-en.html

We SO enjoyed the Eating Europe food tour. Perfect thing to do on your first day: keeps you moving, keeps you outdoors and is a lot of fun. https://www.eatingeurope.com/rome/

Jude, was your visit 10 years ago your one-and-only trip to Rome? I guess I'm wondering what isn't new but you hadn't get seen? Might help if we knew what you've already covered?

Thank you all for the responses.
Kathy - We’ve spent a lot of time in Rome having lived there for more than a year. But because it’s been so long I’m happy to revisit things and potentially be reminded of things we loved!
Dario - We hope to see both Domus Aurea & Torlonia Marbles. Thanks for the suggestions. We did see Quirinale Palace back 10 years ago.
Alan - Didn’t know about Palazzo Valentini. Looks interesting.
Ciao, ciao

We’ve spent a lot of time in Rome having lived there for more than a
year.

Lucky you!!!