Ways to compensate for Rome crowds during Jubilee 2025

I think that sounds like it--other than the mental prep needed to deal with crowds (we all have different tolerances for that).
Where else will you go? I think having a contrast with the busyness of Rome will make for a pleasant respite.

Yes, we are visiting Rome first so we can enjoy the rest of our trip after. We will travel to Florence next and then finally Venice. We have side trips from all three cities.

Not exactly what I meant--those will all be very busy, too--but I am sure it will be amazing!

What did you mean?

Oh like a village or a small city. But it is just a personal preference--certainly nothing wrong with knocking out "the big three," and that is probably what many if not most do. If I was very worried about crowds, I would pair Rome with a lesser visited site for the contrast, but I am someone with low tolerance for crowds.

Most importantly make sure you have firm confirmed bookings at all your accommodations, because that's the busiest time anywhere regardless of Jubilee. Friday April 25 is a National Holiday (Liberation day), Apr 26-27 is a weekend, Thursday May 1 is another National Holiday (International Workers' Day/Labor Day), then there is the weekend. A lot of Italians will take a very long weekend off during that time (as they do every year), so lots of hotels at popular destinations will be booked in advance. That period is actually the only time, years ago, I had a hard time finding accommodations in the center of Rome and had to stay well past the Sports' Palace after the E.U.R. You can always find a seat at a restaurant somewhere, even without reservations, maybe after waiting for a table to free up, and trains very rarely sell out all seats, at most they run out of seats in the cheaper "standard" class and your have to buy in the higher class (premium or business) or wait for the next train later, and ealing with a lot of people around me is not a big deal, at least not for me who grew up in Florence, which has always been busy. However having accommodations in a convenient location is the most important thing to secure in such busy period.

I have a hotel booked. You say firm bookings. Should I be worried that they’ll give my hotel away?

Valadrlphia-

This is my first visit so I have a lot to see. I am making at least one day trip from each, like I mentioned, to less visited places and I’m hoping that will give me a break from the crowds.

I haven't been to Florence recently, but the busiest parts of Rome and Venice are very crowded for most of the year. That's the way it is. I don't know how much slack you have in your sightseeing schedule, but I always have quite a bit, so as I'm walking along in a mob and pass an intersecting street with little foot traffic, I head that way, toward sanity.

I typically plan one activity a day and have a list of others I’d like to do if I can fit them in. Lots of available time. We’ve been to Paris and London/Edinburgh the last two years and had no issues. We mostly avoid the tourist areas in Paris though because we have been there so often.

I have a hotel booked. You say firm bookings. Should I be worried that
they’ll give my hotel away?

They shouldn't but I still like to call and confirm before I go, especially if I make reservation with a third party website, like Booking or Hotels.com.

I got unpleasantly surprised when I showed up at the hotel and they told me that my booking.com reservation wasn't in their system and had to find me accommodations in a sister hotel part of the same chain since they didn't have any more rooms at that location. It happened to me last year in Florence and felt sorry I forgot to confirm my booking.com reservation directly with the hotel.