We have stayed twice in the general vicinity, in Campo de' Fiori, right across the river. Once was in October (crowded in the piazza...vendors by day, partiers by night) and once late Feb/early March (chill & wonderful). Last time, in 2017, we rented a 2nd floor walkup, window opening out to the Campo market, and even with it being off-season, once the vendors packed up and went home, the young Italians were out not in full force, but happy and they whooped it up well into the evening, not obnoxiously, though.
For our next trip April 2025, we will be investigating Campo, as well as the Jewish Ghetto & Trastevere as possible landing spots for a week or so. As stated upthread, I think all the areas are generally safe but be smart--I would not walk long distances home from restaurants late at night. Thus, do your due diligence--as we will--to make sure there are plenty of reasonable restaurants within a quick 5-10 minute walk of your AirBnB.
Only other question about staying in Trastevere, brought up by Mark, is it's a ways from the normal bus line--the 64 (?) that goes directly to Termini station. But this not being your first rodeo, you may have that figured out. Trastevere is very, very cool overall.