We took a bus from the Venice airport to the bus depot next to the Padua train station and then a tram which is across the street from the train station to the tour hotel, which was Albergo al Fagiano. It was not hard.
Here are our directions from May 2019:
Venice Marco Polo Airport to Padua Train Station By Bus
Buses to Padua depart hourly throughout the day and the trip takes about an hour. A ticket costs around €8.50 from the machines at the platform outside of the Arrivals hall, or €10 if purchased from the driver. From there follow the directions “Padua Train Station to the Albergo Fagiano” below.
Padua Train Station to the Albergo al Fagiano
By Taxi
A taxi from the train station to the hotel will cost around €10.
By Tram and Foot
Purchase a tram ticket for around €1.50 from the kiosk outside the train station. Find the stop across the street from the station and to the right (with your back to the station), at the bottom of an elevated street. Ride the tram 5 stops to "Santo". Exit the tram, and with your back to the canal, walk to the far side of the little piazza across the street. Turn right and head down Via Locatelli. The Albergo al Fagiano is ahead on the left at #45.