Dear Victoria, I actually did get into Italy via Istanbul. But I think I may have lucked out and just got a nice guy at the border. I showed him my CDC vaccination card, a negative PCR test within 48 hours, a completed EU passenger locator form, my transfer ticket through IST, and my return ticket. I was also visiting a friend who is a resident of Italy and another who is an Italian citizen, which somehow made a difference under these new rules. The questioning at the border was thorough and intense. Even though it worked out ok for me, as the Delta variant spreads and the rules get tougher, like with green pass, it sounds like the risks may not outweigh the benefit of taking a chance on Turkish Airlines’ cheap fares thru Istanbul… unless you are planning on self isolating in some gorgeous Sicilian villa for 10-14 days (not a bad plan!). Also, on my flight back to Istanbul on Turkish airlines, we missed our landing at the last minute and had to ascend again and circle around. It was harrowing and I’ve never been so scared on a plane in my entire life. No explanation was provided to passengers. So, those direct flights may be the best way to go at this particular time.