Naples has a fixed-rate taxi fare from any hotel to the airport. So if you can afford it, (and print out a copy of the tariff list to show the drive if needed!) the hotel location should cover your tourism plans and comfort level. We walked a very long way from the Palazzo Decumani to the Circumvesuviana (going TO Sorrento) because we're cheapskates! But we thought the taxi from the airport to the hotel was an entirely fair price.
I might add that our program (in the opposite direction from yours) depended on leaving our bags in the hotel baggage room upon checkout to complete our museum (and pizza) visits before heading to Sorrento. And in your situation, I would want a fancy enough hotel that I would feel comfortable having them order an early-morning (licensed, see tariff note above) taxi the night before.