Siena to Venice

Yes, that’s what I would do.

Or you could take the train for both legs. Trenitalia offers hourly service with Regionale trains from Siena to Florence, connecting there to the fast train to Venice. total travel time is 4 hours, including the transfer time at Firenze SMN.

When booking, use the Italian spelling Venezia and pick the Santa Lucia station, not Mestre which is not “in” Venice.

I agree with Suki. When the bus comes into Florence, you're just across the street from the train station. The trains from there are fast and efficient for the 155 mile trip to Venice

Thank you all.

You'll want to take the fast trains between big cities - Florence to Venice - these come with assigned seats on a specific train. The earlier you buy the cheaper the tickets but you're trading economy for flexibility.

The state train company is Trenitalia - they run fast trains and local ones. https://www.trenitalia.com/en.html
.Italo is a private company that only runs fast trains. The service between the two is pretty similar. https://www.italotreno.it/en

Local trains called regionale tickets are always the same price - just buy them when you need them. This includes the train from Siena to Florence which is not a fast train.

Download the Trenitalia app to check schedules, buy tickets and track trains in real time.

Really good general train information here: https://www.seat61.com/train-travel-in-italy.htm

Have a great trip!
=Tod

Thanks Tod!