Rome (and to some extent Florence and Venice as well, but especially Rome) will be significantly more crowded than usual during the Easter week, Good Fri is the 10th. This is caused by two things: the influx of Christians coming from other countries for religious reasons and also the fact that more locals get time off during the days leading up to Easter. Because of the influx of tourists from out of town coming into Rome for religious reasons, if you haven't booked accommodations yet, you should do so soon. Transportation services are also negatively impacted by the influx of people into Rome, trains may be fully booked that would otherwise have seats available, etc.It may help you avoid the crowded time if you do Rome first, but of course the problem is that you're flying out of Rome, I guess on Saturday the 11th.