Rome area with convenient access

Would consider staying in the Aventine Hll area of Rome. It is a quiet area with transit nearby. Rome is a hugh city. If you stay outside of the city you will spend quite a bit of time on transportation into the city center. The Aventine Hill has many b&bs.

Great advice from Becky. If you stay peripheral to Rome you risk spending at least an hour each way coming and going making it hard to just return to your quarters for a couple of hours of rest when you are worn out. Instead, stay in a more residential area like the Aventine or even in Prati, away from the area immediately surrounding the Vatican.

I second the suggestion for staying in the Aventine section of Rome. It is quiet, leafy and residential. We enjoyed the Villa San Pio which is a short walk to the metro which will whisk you quickly into the city. We have recommended this hotel to others and they have enjoyed it as well. The hotel is near the popular Knights of Malta keyhole view of Rome and the Giardino degli Aranci with more views of the city. Our favorite restaurant the Trattoria Pirelli is also nearby. Their artichoke pasta was to die for. I recommend getting a reservation there.

We have stayed in the Prati area our last 2 visits to Rome and loved it. Close enough to sights and filled with locals, great food, and a less touristy atmosphere.

I agree with the others: stay in Rome, but choose a neighborhood outside the touristic center. In addition to Prati and Aventino, you might want to look into Parioli. We stayed once at Aldrovandi Residence because it was summer and we had kids with us, so wanted a pool. Easy walking distance to the Etruscan Museum at Villa Giulia, the Galleria Borghese, National Modern Art Gallery, and of of course the Villa Borghese. We walked most places, but you can also take a quick bus/tram/taxi. There are other hotels nearby if this is not what you're looking for.