Celia,
Here is what my wife and I have been using for the past few trips to Italy.
Me - RS Convertible carry on backpack, Alpenzell day pack(carried) & Veloce guide bag for I-pad( stuffed into alpenzell until arrival at hotel.
Wife - older version of RS rolling bag (slightly larger than new version), Alpenzell day pack & Veloce guide bag for I-pad.
We also use an Eagle creek medium folder for nearly all of our clothes. (1 each)
I am going to try using my Veloce Guide bag (the day pack sized one) instead of the Alpenzell day pack on future trips.. The Alpenzell invites me to take to much stuff so I/m downsizing. We have both versions of the RS Rolling bag. My wife chooses to use the larger one. We use the newer one for domestic trips. We're both over 60 and so far this works for us.
Good luck & have great trip.
Gene