You’ve got full activities and sights each day, without trying to do 20 things in the morning and another 15 in the afternoon - looks quite doable; keep up your nutrition and factor in time for lunch and/or a shot of caffeine. Day 2 in particular will require a good amount of energy. I bet you’ll find San Clemente fascinating. I saw it for my second time last September, although I wasn’t aware that they wanted me to have purchased my reservation for the subterranean excavations ahead of time, and weren’t allowing on-site cash or credit card purchases. Well, there was no Internet connection inside the basilica, so I couldn’t book an entry right there on my phone, but the ticket taker took pity on me and another woman behind me. She took our €10 apiece and I got in. Better if you have your voucher ahead of time.
Appian Way: two years ago, we rented bikes (not eBikes) from the “cafe” listed in Rick’s guidebook, and attempted to ride the cobbles. It was a weekend, when car traffic was supposed to be restricted, but there was just enough traffic to make things pretty challenging. There were also bus loads of school kids, plus hundreds of other pedestrians covering much of the width of the roadway, and that was enough to make things really really challenging. There are dirt trackways along the banks of the roadway in places, so it’s kind-of a mountain bike course, shared with other vehicles, and possibly hoards of pedestrians, walking in the opposite direction, and no understanding of who’s got any right of way, or keeping to a particular side of the road. The rough cobbles and breaks in the road were unforgiving, as were roots across some of the dirt paths on the side, attempted when the roadway was extra crowded. Between stopping when the path wasn’t clear, swerving onto the banks on either side, steering to avoid people who weren’t looking for bikes coming the opposite direction, or thinking about sharing the road with us, it was not a smooth ride. Oh, and that’s not even mentioning the rough paving stones. Maybe your eBike tour is a group activity, with a ride leader. If so, they may provide some tips on getting down the road safely.
Eating Europe does a Testaccio food tour that’s enjoyable and enlightening, and worth taking, but it starts at 9:15 AM. That won’t fit in with your current itinerary, unless you scrapped the Appian Way ride (which I will not be doing a second time - not on a bicycle, anyway. I’d also definitely re-visit the Baths of Caracalla, on the south end of Rome on the same road that heads towards the Appian Way.
After enduring the Appian Way bike experience, we caught the afternoon’s last San Sebastian catacombs tour. Even though you’ve been to the Borghese before, and sounds like you won’t be seeing those Brunelleschi statues this time, the church above the catacombs has Brunelleschi’s final carving inside - a bust of Jesus. If you see those catacombs, see his last work!