Quadruple rooms in Venice

If you're staying at least 3 nights you might want to consider renting an apartment, it'd probably be cheaper.

I've stayed twice at Residenza Ca' Foscolo, and loved it. It's an apartment hotel with several apartments all in the same building. They're clean, modern, spacious, and really well located between Rialto and San Marco. I'm not sure of the configurations of all the apartments, but I've stayed in a two bedroom that slept five adults comfortably, as well as a one bedroom that was much more than enough for the two of us. No problem staying two nights. They've got lots of good reviews on tripadvisor.

I wanted to stay here http://www.vrbo.com/191119#features but it's too big for us with NINE bedrooms! Maybe it will work for you.

Definitely consider apartments or a house. That place Laurel found looks amazing. And it's in a wonderful part of Venice.

We are spending two nights and have looked into apartements however, most require three days. Additionally, it was hard to find three apartments next to each other. Thanks. Any hotel or pensione recommendations?

Normally I just call the hotels on my list and tell them what I need. In Venice, I called Hotel d'Art for five of us and they offered an apartment, conveniently located at a great price. It wasn't fancy but worked perfectly for us.