We have two nights, and I keep changing this portion of our trip. We will have a car and will be driving to one of these locations from Munich, and then driving from this stop to Siena. Thank you!
Roberto's comment about covers it!
Portofino will likely cost you more and will have harder to find parking, especially on weekends. Portofino has a lot of stuck up rich V.I.P. people that I can't stand. Both are pretty towns.
why not try Rapallo? We have stayed there twice and loved it. It's a 30 minute drive to Portofino.