Planning our 1st trip (10 days) thinking Florence - Venice - Amalfi Coast

Fly into Venice, then train to Florence. You are skipping Rome? You will take train from or at least through Rome to Naples.
Florence is in Tuscany. Why not also stay out in one Tuscan countryside or at least in Siena?
Amalfi Coast is the outlier, a long trip with changes in transit. How so you plan to travel to the Amalfi
CoSt from Naples. No trains.

Ten days is not enough to do all you hope to do or at least it will be a blur. Save the Amalfi Coast for another trip concentrating on southern Italy.

My recommendation would be to read a guidebook on Italy. One like Rick's, which will give you good ideas of what to see in each place, so you know how many days you need in each place. Only then will you know how many places will fit into your allotted time.

Look at how many NIGHTS you will actually be in Italy, for planning purposes. Don't count your departure day from the US, or your return day. And consider that you will lose 1/2 a day to travel every time you go from one city to another. With only 10 days, is that 10 nights in Italy, or only 8?

Way to stretched out, geographically, to be practical.

Need more days or a more compact area.

Definitely get a guide book, RS or any other and see what interests you

You do not have to take a tour, but you may want to look at this itinerary to see what 10 days can cover, on a well laid plan. Use it for ideas.-----https://www.ricksteves.com/tours/italy/venice-florence-rome

Count nights on the ground. The number of days you have is one less than the number of nights - your first day is mostly lost getting through the airport to your hotel, lunch and then trying to stay awake long enough to get a good night's sleep. Your last day is going to the airport. Every time you change locations, you use about 1/2 day (packing, getting to/from station, etc). If you have 10 nights, that's 9 days, or 2.5-3 days each in 3 locations. Going to the Amalfi coast eats up even more time because it is both far and requires multiple modes of transport, plus it's not convenient to any airport, so you'll need to move to another place for the night before your flight home.

Thank you. We are staying for 10 nights after arrival in Florence. Original thoughts are to spend 5 nights there and 5 in the AC, either in Salerno or Sorrento. Day trips from Florence would be a food and wine tour one day, Siena on another. Possibly a day trip to Venice just to experience it, maybe not.
Opinions on Sorrento vs. Salerno?

In case we cut a night from FL and do an overnight in Venice, has anyone flown on EasyJet from Venice to Naples? They have a 7AM flight. Trip is late April into first week of May. Thanks again for all your comments.

Congratulations on taking your first trip to Italy. You'll have great time no matter where you end up as long as you don't try to fit in too much. You can always go back and do Rome only another time.

In case we cut a night from FL and do an overnight in Venice, has anyone flown on EasyJet from Venice to Naples? They have a 7AM flight. Trip is late April into first week of May.

Last February, I had the choice of plane or train from Venice to Naples, where I spent several nights. I chose the train even though it added about an hour to the travel time because it's a pain to get to the airport in Venice. But you aren't going to Naples, so flying probably won't save you any time, since you'll still have to get from the Naples airport to the Naples train station. What about flying into Venice and out of Naples? If you must fly into Florence, I don't think it's worth it to visit Venice, either day trip or overnight.

Salerno vs Sorrento. It's easier to get to Capri and Herculaneum from Sorrento. It's about the same to Pompeii from either. I think it's easier to visit the Amalfi Coast from Salerno. From Salerno you can day trip to Paestum for the Greek temples. Salerno's hotels and restaurants are cheaper. It's easier to get to/from Salerno because there's fast train service to Naples/Rome/Florence. To get to Sorrento, you have to change to the local Circumvesuviana train (think metro, not "real" train). Salerno is mostly on level ground, the ferry and buses are a few minutes' walk from the old town. Sorrento is perched on the cliffs, so the train station is uphill from the center, the ferry is down a whole lot of stairs.

Thanks Chani for all the information, very helpful! I think we have decided to do 4 nights in Florence, then 2 nights in Venice and 4 nights in Salerno. I'm so looking forward to it!

In Salerno, I stayed at a small B&B (Salerno Centro B&B) that Jay fro Chicago recommended to me and I loved it. If you can, take the Positano room, it has an en suite bathroom. The other 2 rooms have their own bathrooms, just across the hall from the room.