From the Milano Centrale train station:
Stresa, Italy (IT) (Lake Maggiore) 1h by direct train.
Bergamo, IT 1h by direct train.
Varenna, IT (Lake Como) 1h 15m by direct train. After touring this clean quaint town lined with Mediterranean cypress trees hop on a 15m ferry to Bellagio with a mountainous backdrop with storefronts displaying high-end merchandise along its scenic sloped alleyways.
Bologna, IT 1h 15m by direct train.
Torino, IT 45m by direct train to Porta Susa..
Verona, IT 1h 30m by direct train.
Parma, IT 1h 30m by direct train.
Florence, IT (to SM Novella station) 2h by direct train. Plan on taking multiple trips and make reservations for the Uffizi Gallery two-months out to guarantee a reservation.
Vicenza, IT 2h by direct train.
Venice, IT 2h 45m by direct train.
Alba, IT (Piedmont region) 3h by train and requires a change.
Ravenna, IT 3h 15m by train and requires a transfer.
Bozen Bosen, IT (Bolzano) 3h 30m by train with a transfer.
Trieste, IT 4h 45m by train and involves a change.
Lugano, Switzerland (CH) 1h 45m by direct train.
Bellinzona, CH 2h 15m by direct train.
Luzern, CH 3h 45m by direct train.
Bettmeralp, CH 2h 45m requires a train and cable car transfer.
Lyon, France (FR) 4h 30m by direct train.
Nice, FR 5h 15m by train and requires a transfer.