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One week in Tuscay - Manciano

My wife and I have booked a villa in Manciano for a week in October. We will be spending a few days in Rome before we travel to the villa.
Suggestions for seeing the Basilica, the Coliseum and the Sistine chapel on a Friday afternoon and Saturday morning? We will be spending the night in Rome on Friday before we pick up our car at the airport on Saturday to travel to Manciano. Any and all suggestions are welcomed!!
Any knowledge of Manciano and things to do etc would also be appreciated.

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