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Neighborhood in Rome

This will be our 5th trip to Rome, and we've always stayed in Trastevere. I'm reluctantly thinking of a new neighborhood to rent an apartment in, and I'd love some ideas of somewhere that is similar in terms of nightlife and vibe. We get out and walk around all of Rome when we are there, so we are very familiar with the city, but does anyone have a place that they love that they can tell me about?

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If you are looking for nightlife and vibe, I don’t think there is a better place than Trastevere. The other option is the Centro Storico (basically between Campo dei Fiori to Piazza di Spagna). That area is equally vibrant but accommodations are likely a bit more expensive.