Naples with bad knees and back

The area near Piazza Plebiscito and the Chiaia Metro station is nice and is not hilly, plus you have several transportation options if you don’t want to walk.
The Vomero neighborhood is very upscale and nice but very hilly.

The metro system in Naples is excellent and most stations have elevators. I would not take a walking tour. Pick some places you really want to see and concentrate on the best ways to get there. Google maps allows you to put in wheelchair accessible as a search option which will let you see which bus routes have lifts if needed. Are you locked into your accommodation? I use a wheelchair for any distances over a few blocks. I always make sure any accommodation has an elevator.
We always stay in Vomero near a metro station. We like Vomero because it is calmer and has wonderful streets to stroll and explore.

We have walking issues so took a hop on hop off bus tour. There is a stop by the Archeological Museum. The Main Street in front of the museum is flat and leads to simple restaurants and the busy local market street. All downhill from the museum to the port/train station.

Hi there, are you still planning on Florence, Rome & Naples? (I looked at your thread about clothing in November.) Frankly I would also be concerned about Rome - You will want to think ahead to avoid hills there, or climbing stairs for example to the Capitoline museum.

I also wanted to ask if you're planning a day trip to Pompeii or Herculaneum? Because frankly with bad knees I would skip Herculaneum since there's no avoiding a large hill you have to descend & go back up. There's an accessible route coming into the Pompeii ruins from the Amphitheater entrance, which would avoid a steep hill at the main entrance. Let us know, I'm sure there's more advice here about Rome as well. I hope your trip goes well, being in pain is no fun.