Naples to Venice With Rome, Pisa, Florence, Turin Inbetween

With only 10 days I would limit the number of stops so you really have time to see a place. Is there places in particular you really want to go? Have you been to any of these cities before? Looks like you mainly want to visit cities, so traveling by train makes more sense than a car. Turin is in a different direction, so you may want to skip this one.

10 days? Does that mean 11 nights so you have 10 FULL DAYS on the ground?

Pick 3 places, max, to lay your head. Naples and Turin are outliers by far for a 10 day trip. You can barely see Rome, Florence, and Venice. Pisa is possible as a side trip from Florence but it really is not that great. Florence has much more to offer.

You do not need or want a car in any of the cities so make it easy on yourselves and take the trains. Faster, too.

We just did Sorrento (Naples), Rome and Venice in 11 nights. I can't imagine trying to cram 3 more cities. I agree with other posters, choose 3 and spend a few days in each. Enjoy!!!

Do rail for sure. Enjoy a drink in the bar while the landscape flashes past at 300 km/hr. Naples to Rome is about an hour and a half by train.

10 days? Does that mean 11 nights so you have 10 FULL DAYS on the
ground?

Great question from Laurel. Even with 10 FULL days (subtract arrival and departure days) you don't have time to do 6 locations any sort of justice. It's barely enough time for Venice, Florence and Rome, all of which offer a great deal to see, and all of which take time to settle in and learn to enjoy. LOL, I often think that some visitors who report disliking any of them feel so because they tried to cram days worth of attractions into just a few hours. The "top" of those attractions are usually the most overrun with tourists so having to spend ALL of a very short time surrounded by the mob can get old fast.

You'll want to spend more of the time/money you have sightseeing and less of it packing/unpacking, checking in and out, and in transport from place to place. As suggested, I'd scrap the outliers (Naples, Turin) and probably Pisa as well. With adequate number of days allotted for Florence it could be done as a day trip although I'd also agree there are better choices than that one.

Trains are definitely the way to go for too many reasons to list but the short of it is that they'll cover the distances faster and with none of the headaches/expense of parking, toll roads, dodging ZTLs, risking theft of unattended bags in the car, etc.

Unless you have a reason to spend a lot of time in Pisa, visit as a 1/2 day trip while you're staying in Florence. You'll use about 1/2 day each time you move. I wouldn't recommend Naples/Rome/Florence/Venice with 10 full days unless your group likes a fast pace.

Day 1. land in Naples (2 nights), jetlagged. Push yourselves to stay awake, see a little of the city
Day 2. full day, visit Pompeii or Herculaneum ruins and the archaeology museum in Naples, use the evening (if you still have strength) to see the city at night
Day 3. train to Rome (3 nights). Lunch, afternoon/evening sightseeing
Day 4. full day Rome
Day 5. full day Rome
Day 6. train to Florence (3 nights), Lunch, afternoon/evening sightseeing
Day 7. half day Pisa, half day Florence
Day 8. full day Florence
Day 9. train to Venice. Lunch, afternoon/evening sightseeing
Day 10. full day Venice
Day 11. fly home.

In any event, I'd reverse the order. Venice is low key, a great place to get over jetlag and just soak up the atmosphere. Naples is the total opposite and I'd never recommend for anyone to start their first trip to Italy there. If you have fewer than 11 nights, skip Naples. Even the above itinerary shortchanges every one of your stops.

Trying to do all your destinations in 10 days sounds like you (a) lost a bet or (b) took a dare. It does not look like a vacation.

You need more time or fewer destinations to have any reasonable expectation of enjoying your trip.

"Back to the drawing board" is a phrase that comes to mind