Tim - It is my understanding that the lines at the Vatican museum have all but disappeared given new management. I was there two weeks ago and had booked a tour company for the very same reason - to avoid the lines. I was supposed to meet our tour guide at 2:00 p.m., but they did not show up. I was there at 1:30, and so I had time to watch the line to get in. During the entire 45 minutes that we waited for the tour guide, the line moved quickly and I would estimate that the wait was never longer than about 5 minutes. When it was obvious that my own tour guide wasn't going to show up (thankfully I hadn't paid anything yet), we simply got into the lineup ourselves, waited no more than 5 minutes, and went inside. We used the Rick Steves podcast, that I had downloaded onto my iPod, to guide us through. The money that we saved on the tour guide, and it would have been quite expensive, was used on a nice bottle of wine that evening for supper. Just a thought ...