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Late March 2025 flights Rome to Palermo?

Disregarding cost, would you take an afternoon flight from Rome to Palermo in March on ITA or Ryanair? We have never flown on either airline.

We are flying Delta and KLM from Minneapolis, and the layover time at Rome airport for ITA looks short (about 1.5 hours) and for Ryanair is a bit long (4.5 hours). I assume we'd have to retrieve and re-check our checked bags either way.

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The layover time might actually be the determining factor for you. The 1.5 hours is a bit too risky for me unless there are more flights afterward that you could be put on. (Some of our biggest snowstorms occur in March.) I would probably opt for the 4.5 hour layover and just enjoy a meal/drink in the airport while waiting.
I also will be flying ITA for the first time this December, Rome to Palermo. I'll be interested to see what others say.