What is the best way to get from Lake Como to Lake Maggiore?
They are two big lakes, so it depends on where you are at and where you want to go. There is hourly service from Como San Giovanni to Locarno with changes at Chiasso and Giubiasco. 1 hr 47 min. Bus service? That may take a bit of research. www.rome2rio.com?
As Sam mentioned it depends from which town on Lake Como you come from and to which town on Lake Maggiore you go to. Since most followers of the Rick Steves' cult go to Varenna on Lake Como and to Stresa on Lake Maggiore, I'll assume you belong to the same cult and will be using those cities. In that case the fastest way is a train from Varenna to Milano Centrale and then another train from Milano Centrale to Stresa. Total travel time is approx. 2 hrs and 45 min.