I visited the Jewish Quarter for the first time and even though I'm not Jewish (or even particularly religious) it was still an evocative experience and well worth the trip. I think context absolutely helps so I would read up and or research the history of the quarter some. The very word ghetto comes from this place in Venice as RS covers in his talks about it.
The program Invisible Cities had a great segment showing how the various synagogues were built into and across buildings to fulfill the needs of the people. (All three segments are amazing if you can watch them - it was where I learned about The Vasari Corridor in Florence.) I considered a tour of the Jewish Quarter but all the ones I found were very Jewish with visits to synagogues and seemed like more than I was looking for as an outsider but a historical tour that includes the Jewish Quarter would probably very interesting.
My $.02. Venice is amazing - enjoy!
=Tod