Thanks to the many suggestions from the first question I posted, I've compiled an itinerary. It's a version of the one from Rick Steves' Rome book. We would leave home on a Saturday and arrive Sunday. Because of jet lag, I made the first day lighter. I would appreciate any suggestions/changes/etc. My spouse and I will travel with our sons 18 and 20. We arrive in Rome on a Sunday at 9am and depart the following Saturday at 11am.
Day 1: Walking tour of ancient Rome (in Rick’s Rome book)
Day 2: Colosseum, Forum and Pantheon. Dinner on Campo de’ Fiori and Night Walk Across Rome to the Trevi Fountain and Spanish Steps.
Day 3: St. Peter’s and the Vatican Museum. Evening: walk the Via del Corso from Plazza del Popolo (go there) to the Spanish Steps.
Day 4: Borghese Gallery and the Capitoline Museums. Rent cart.
Day 5: Side trip to Ostia Antica, the Appian Way and the Catacombs of Priscilla, or Tivoli.
I would like to add: National Museum of Rome, walk through Trastevere and Jewish Quarter but don't know if there's time or if so, when to add that.