I am planning to rent a car when we arrive in Rome and drive to Orvieto. Spend a few nights in Orvieto, and drive to Siena for 5 nights, and then drive to Como for 5 nights. Finally, turning in the car at MXP and spending a couple nights in Milan before flying home.
Has anyone done something similar? If so, do you have any advice? My other option is to take the train, and only rent a car in Siena for touring some of the surrounding hill towns.