Itinerary details are not clear
Could you repost that bit?

So much for my typing.

1

Rome direct
Isca 3nts
Capri 2
Rome 2
Menaggio/ Bellano 3
St. Moritz 1
Zurich 1
! more maybe somewhere

2

Rome direct
Isca 3nts
Pisciotta or somwhere on Cilente coast 2-3
AC 2 (I like he never been)
Capri 2 (I like he never been)
Orvieto 1 (maybe worth spending night)
Rome 2 (coliseum- /day trip possibly)

Roundtrip from Toronto

I think plan 2 makes better use of your time. I also loved Pisciotta!

The first option feels like you’re adding Switzerland without thinking about how much time you need to both get there and also to enjoy it. The travel time between those locations will really eat into any enjoyment, plus you need to consider that sometimes the mountains can be clear in the morning (or vise versa) and you missed the opportunity to have a nice hike. I usually do multiple 1-night stops on trips, but I wouldn’t in this area.

If you want to see Lake Como and Switzerland, then fly from Lamezia Terme and skip Rome (have 1-2 days in Rome at the beginning?) and skip the Amalfi Coast region and fly up to Linate & go north from there.

The second option takes a nicer advantage that you’re already in the southern area. Orvieto feels like a quick add on. I had it on my upcoming trip to the Puglia region that ends up near Rome, and I ended up pulling that 1-night in Orvieto off my stays. How about just add the one day stay to Rome, and give yourself the option to go from Rome to Orvieto, or Tivoli, or Ostia Antica or ? when you’re there.

I would do option two, with one tweak. As you want to see Orvieto, go there first on arrival in Rome, have 2 nights there to get over jet-lag, then make your way to Isca. I'd probably decide between either Amalfi or Capri as they are both very busy and make it 3 nights.

Very interesting, and unusual, what you write about Venice. Being selective while planning and travelling is essential, and when I go there I will generally avoid the Grand Canal except for the bridges. This means a reply could be useful;
After a few visits to Italy, and having perused an abundance of guide books from cover to cover, those lakes are at the top of my list of places to avoid. Too mannered, too up-market and quaint in the wrong way, and too cold and austere, they seem like a place long since conquered by the affluent moneyed classes, and that kind of exclusive enclave ambience quickly ruins any attempt at relaxation, even if there should still be some genuine villages dotted here and there. I would even rather go to Milan than have to visit them. We have a million lakes back home. Maybe you do too. The Mediterranean is about the sea and landscapes with ancient ruins, olive trees and serenading cicadas.