Italy 10 days with some mobility challenge

This may help you for the Venice portion of your trip.

https://europeforvisitors.com/venice/mobile/articles/accessible-venice.htm

For Rome would you be open to using a wheelchair? This place rents them.

https://www.mobilityequipmenthiredirect.com/mobility-equipment-hire/c447-wheelchair-hire-in-italy-rome/

Thanks Gerri, that is VERY helpful. Info from persons with experience is invaluable. That's why I came on a forum for the first time. We haven't booked our tickets from Toronto yet, so we can stay longer than 10 days. Going back thru Amaterdam to see my mother-in-love.

Assisi is very hilly, some lanes are so steep they only have stairs, I wouldn't recommend it for you with or without a wheelchair. Florence is level, the only problem would be that some of the streets are cobbled, some have potholes. I'd consider that instead. It's also on a direct train line between Venice and Rome. You may not even need a wheelchair there.

The main problem in Venice is going over bridges in a wheelchair. But if you can walk over them while your husband pushes the empty chair, that shouldn't be a problem.

In Assisi, take a look at the Dal Moro Gallery hotel. Very modern, very sharp. From memory, it has an elevator. It is not in actual Assisi, but is down the hill near the Basilica Santa Maria degli Angeli. If you are there on a Sunday evening, do attend the service. It is most profound.
With mobility issues, the Cinque Terre might not be so well advised.

I don't seem to see any reference to 'wheelchair' in the original post.
@Katemooij, were you considering a walker or a portable stick seat? Or are you in physio to be able to become more mobile? I would certainly get advice from your rehab team as to any aids you could buy or rent to help you enjoy your trip. With 9 month to go, you may have built more resilience.
Do ensure that lodgings have elevators from the ground floor. Some require to climb stairs to the 1st floor (our 2nd) where the elevator is located. I don't want to recommend ground floor rooms as they are often noisy as close to front desk and foyer with frequent comjng and goings.
I wanted to recommend a vaporetto pass to help get you around Venice easier, but that may depend on your agility, or the vaporetto design for those with mobility issues. Check the link above for information on that. Also, taxis or Uber are your friend.

Thank you Chani, Aussi and Maria. After 3 surgeries, I walk with a cane. It's slow going up stairs, but I can do them. In Rome, a wheelchair might be useful but it isn't a necessity. We chose March because it will be less crowded so hopefully my turtle speed won't disconcert other travellers. I'm stubborn, so I think we will do Assissi, but Florence is also appealing. Good to know about the noise on the ground floors. I can easily go up one flight of stairs. With 10 days can we do four places? We will go to Amsterdam first to get over jet lag and hopefully to allow for a few degrees warmer. In terms of costs, how much did you all spend in 10 days, including hotels, if you went to historical and cultural sites? Perhaps the costs of Steve's tours are a good indication. Don't want to scrimp. Having an idea ahead of time is informative. Advice is much appreciated as we begin planning.

Congratulations! A walking stick with a foldable seat is recommended. That way you can sit and take a break as needed. In Venice the vaporetto will be the best getting to San Marco square. If you decide to go on foot, the route through the Cannaregio section has the fewest bridges and is relatively flat. In Rome, I recommend staying in the historic neighborhood aroud Piazza Navona or the Pantheon. It’s centrally located with many pedestrian only street. The taxus, buses and trams in Rome are recommended.

"With 10 days can we do four places?"

That's a bit fast, but doable, for someone with no mobility impairment. With your difficulty walking, I think that's too much. You'll have a better trip if you limit it to 2 or 3 places; that way, even with the extra time it will take you to get to places, you'll be able to see what you want instead of missing things.

"We will go to Amsterdam first to get over jet lag and hopefully to allow for a few degrees warmer."

Warning: many of the hotels in central Amsterdam do not have elevators, and due to historic building codes, are not allowed to install them. The "stairs" in Amsterdam are more often like ladders - as in, "you really expect me to go up and down that thing?" steep. So, either get a room on the ground floor, or make SURE your hotel has an elevator (these do exist).

Note that in Europe, the first floor is above the ground floor, not on the ground level as in the US. So the "second floor" is up two flights of steps.

"In terms of costs, how much did you all spend in 10 days, including hotels, if you went to historical and cultural sites? Perhaps the costs of Steve's tours are a good indication."

Rick's tours are costlier than I spend going on my own. For that extra money, you get a tourguide and driver, plus you get all the planning done. So, I'm not saying they're bad value, but they do cost substantially more than doing it yourself. You can't use them as a price guide to DIY pricing.

In your case, you will be spending more money on taxis and less on buses than most, and you may need pricier hotels to get the accessibility you need. So, other people's budgets in those areas may not apply to you. Airfare, food, and attractions will be the same.

Rick used to have a book Easy Access Europe. It was last published in 2006, so it's outdated, but still has some useful information. He provides it free on this website as PDFs. Of your specific destinations, it only covers Amsterdam, but the general information may still be relevant: https://www.ricksteves.com/watch-read-listen/read/easy-access-europe

Here's Rick's Travelers with Disabilities page, with lots of links on the right hand side: https://www.ricksteves.com/travel-tips/trip-planning/travelers-with-disabilities

I think you can do Assisi as a day trip from Rome on the train. That might be easier than changing hotels.

We have just returned from five weeks in Italy, staying in Venice, Naples, Spoleto, Florence and Milan. Our costs, not including accomodation, ran out at 115 euro per day. We stayed both in apartments and hotels, but for a couple 115 euro a day seems OK. Add to that number hotels, train and air fares.

I had a major fall 3 weeks before our Italy trip that included Rome. By trip time I could go up stairs, but going down was a real issue, so I concentrated on who had handrails. Capitoline Museum had rails on the sides, but Spanish Steps do not (and people sit along the sides).

The biggest budget items are trains and hotels. Those are individual choices based on several variable factors. Expect low season prices in March for rooms. You can get an idea from going to a site like booking.com or hotels.com and pricing various level hotels in the places you're thinking about. You may see "no availability for your dates" because smaller hotels (boutique or basic) may not yet have set their 2020 rates. Just off the top of my head, I'd expect €100-150/night to be a decent estimate, and you can find places that are less than €100 that are perfectly adequate - but that depends on your requirements - a view, a balcony, spacious room, Old World charm, will all add to the rate. You can find train prices on the Trenitalia site - note that if you book no-change tickets well in advance you get considerable discounts, so look now at trains for mid-October. Costs for food, sights, tours, etc., are about the same as other European countries, a little less than France, a little more than Spain . . . .

Thank you everyone. The information will assist us as we plan. I'm going to wait until the high season is over to see what rates are posted for March 12 onward. Had a friend tell me on the weekend, NOT to go to Assisi, as I was cautioned against on this site too. (I'm stubborn but not unwise) So maybe Florence, Venice and Rome. Next year, CHINA!!!

We just returned from Italy. I would not do Assisi or Cinque Terre as they have a lot of hills to navigate if you have mobility issues. Venice has bridges that you will need to go over but if you can take it slow I think Venice is a beautiful and unique city to see. You definitely won't be driving in Venice as it is all canals. In Rome, I would take taxis and not try to drive and find parking spaces. Hope this helps.

Yes, thank you, it is helpful. Wonder if we should drive or take the train to Florence? We like being able to get out and stop when we want to do so. It allows us to meet and talk with locals in every country we visit. So if anyone has a recommendation on that , please let us know. We are not timid drivers, having driven in Mexico, India, from Amsterdam to Poland, Germany, France, to England and back and every year in Jamaica.