Is this Florence itinerary manageable?

It all seems well paced and planned to me. Just a minor suggestion or two:

The Firenze card gives you a nice opportunity to pop into some smaller sites like Orsanmichele, Santa Croce or Medici Chapel without as much planning. Pay attention to your maps on your walk, and you can probably see some of these in the late afternoon rather easily. Palazzo Vecchio is open late and free on your card, it can make a nice stop if you’re still kicking after dinner.

San Marco museum is right by Accademia, and not much else. I would group these together. Personally, we found this museum rather disappointing (especially in comparison with other sights.) Also, Accademia is actually small and doesn’t take that much time to see, unless you try to. You’re under no obligation to look at their paintings, you’ve got bigger fish to fry at Uffizi.

The interior of the Duomo can be a bit of a letdown. There’s a massive line, and most of the art is in Duomo museum. I would do the museum before queuing up for the cathedral interior.

I think Santa Maria Novella is tops for art lovers, I would make time for it.

Not sure of the date of your visit, but the Bargello Museum has normal hours of 815-14:00. Last entrance at 13:20. Doesn't leave you a lot of time after lunch to visit. And this underviewed museum is worth the visit. Also closed 2 Sundays and 3 Mondays a month.

When we were last in Florence (2017) we saw long lines for the Duomo interior so we kept walking and returned when there was no line. Biggest line is for the dome climb -- which requires tickets (available at the office across from the Baptistry.) Baptistry is well worth seeing, no or short line.

For me, San Marco is a must-see due to a long-time love for Fra Angelico. Or just walking around surrounded by Renaissance buildings.
Enjoy!!

Another fan of San Marco here; we preferred that one to the Medici Chapels. Do be aware that it is closed on the 2nd and 4th Monday of each month. Very nearby is Piazza della SS Annunziata: be sure to at least walk through it either coming or going from S. Marco:

https://www.visitflorence.com/florence-monuments/piazza-ss-annunziata.html

And if possible, stop into the church; admire the frescoes (restored in 2017) in the entrance Cloister of the Votivi.

https://www.visitflorence.com/florence-churches/santissima-annunziata.html
https://archaeologynewsnetwork.blogspot.com/2017/11/major-restoration-of-renaissance.html#0tZq6B1D662jqBKl.97

You'll also get an interesting view of Brunelleschi's dome from a spot in the piazza.

Honestly, I don't know as I'd go to the Pitti just for the Boboli, even if you have an interest in gardens. Understand that they are almost devoid of flowering anything - it's not 'that' sort of garden - and the lawns could be pretty dry/brownish and water in the non-operating fountains green and scummy in late summer heat. Just read up on it and its condition in July-August, before making the decision to go? Be ready to do a LOT of climbing, and it likely will be uncomfortably warm so bring a hat and water.

Good planning. Wednesday might be a bit crammed, but you may get it all down. Love Florence. I loved Accademia and the Uffizi, but the Pitti Palace was just OK.

Tuesday your Accademia reservation is at 10 and you want to do the Medici Chapels prior to lunch. We spent 2 1/2 hours in Academia, not sure that will work for you.

I also love San Marco-it's a rare opportunity to see art in its original environment.

Thank you for all the advice. These are exactly the types of suggestions I was hoping for. I will rearrange Monday's schedule and double check closing times for some attractions. I will also try to find a time for Santa Maria Novella. Based on what people have said I think we will skip Pitti Palace since we will have seen gardens in the Lake Como area. That will free up a large chunk of time and we possibly could get to San Miniato for the 5:30 Gregorian chant service. We also enjoy music, but did not see a way to fit it in on this trip. This might give us an opportunity.

As far as the walking goes - I plan on thoroughly enjoying Italian cuisine on this trip, so I will need a few strenuous walks!

Jennifer

Oooh! Trying to get to a Gregorian-chant service is an excellent choice, and you'll wear off some pasta puffing up to the church and Piazzale Michelangelo! :O) There are couple places near the piazza to grab a beverage and rest your heels.

The climbing I mentioned before before was for the Boboli Gardens but San Miniato trumps that one. If you have time, take a look at Cimitero delle Porte Sante (the church's cemetery) while you're up there?

https://www.atlasobscura.com/places/cimitero-delle-porte-sante-sacred-doors-cemetery

One more church if you can fit it in? It's free!

https://www.visitflorence.com/florence-churches/santa-trinita.html

The Sassetti Chapel in this church is a must for art and history lovers as Ghirlandaio painted his patron, patron's family and other citizens of the time into the frescoes as they really looked; photographic illustration. He even inserted an image of himself into the far right edge of the "Resurrection of the Boy" fresco. Take special note of the clothing, and the scenes which are set in 15th-century Florence.

http://www.travelingintuscany.com/art/ghirlandaio/sassettichapel.htm
http://readingrenaissanceart.blogspot.com/2015/12/the-sassetti-chapel.html
https://www.wga.hu/html_m/g/ghirland/domenico/5sassett/index.html

It's near the next bridge west of Ponte Vecchio.

I second the view from Piazza Michelangelo (or climbing higher to the church). There's some yummy pizza at Gustapizza in Oltrarno- busy, tiny little place great for lunch. If it helps your scheduling, we were just there and spent about 2 hours at Uffizi and about 45 minutes in Accademia. We did the RS audio tours in both.