Is it possible to visit the Sistine Chapel before the Vatican Museum collections?

Hi, Giangilberto from Milan.
It works like any other museum, once you've bought the ticket you can move freely inside, so if you want to go straight to the Sistine Chapel you can, and then come back and visit the rest of the collections.
There's no set route and nobody stops you.
So it'll be the same experience you had twenty years ago. That hasn't changed.

There’s not a mandated one-way route, but crowds that arrive after the 8:30 entry time may hamper backtracking, just because you’ll be “swimming against the flow.” Our most recent visit, just a few years ago, was so much more crowded than our first one 14 years ago, especially inside the Sistine Chapel itself. I don’t know what your situation was 20 years ago, but don’t be surprised if crowds affect every aspect of your visit to the Museums and the Chapel. I suspect it will be a noticeably different experience this time around, but I do hope your Sistine Chapel plan works for you.

My family took an early morning highlights tour (booked through the museum itself) that ended in the Sistine Chapel. The tour began before the doors opened for general admission, and we were able ti go back and spend as much time as we wanted afterwards. Seeing the Chapel that way was fantastic.

Hey Scandifan, thanks for info about earlier entry before general public into Vatican museums, that's not the Key Master super expensive option. Very useful for our next visit!

For those of you who might like to book directly with the Vatican, I believe this is their official site. https://tickets.museivaticani.va/home/

We're taking a somewhat opposite approach when we're there in October. We booked the last tour of the day and we will slowly make our way through the museum hoping by the time we get to Sistine Chapel near closing time, it won't be too crazy.