hotels in milan

In March 2011, we stayed at the Hotel Gran Duca di York (www.ducadiyork.com). It was listed in Rick's Italy book. It is more of a business hotel, but was clean, quiet, comfortable, served an excellent breakfast, and had a very helpful staff. Location-wise, it is literally across the street from the Pinoteca Ambrosiana and a 5-minute walk to the Duomo.

We enjoyed staying at the Best Western Major. Very modern, large rooms with a breakfast buffet included. Right by the metro station that takes you directly into central Milan.

I've stayed in the Hotel Berna and Hotel Garda in Milan. They are just a couple blocks from the main train station, lots of metro stations, restaurants, GREAT location. They were both excellent and considered budget hotel. The Berna is just a bit more than the Garda. (they are across the street from each other.)
You can research both and see photos on tripadvisor.