We just left Venice and stayed at a great hotel - Ca’ Pisani in the Dorsoduro neighborhood. Well appointed room in a quiet area, huge breakfast buffet and helpful, friendly staff.
This neighborhood is quieter than the San Marco area. There’s a great plaza- Campo St Margarita. Quite a large area with many places to eat/get an apertivo. Since it’s away from the touristy area it’s mostly locals and uni students
We highly recommend the restaurant Bakaro- small osteria. Had our best dinner in Venice.