Getting to the Vatican

I think I understand your question. Roman streets sometimes change names every few blocks. It is a bit challenging until you get used to it. Will you have a smartphone so you can follow walking directions on it? Or print out the Google directions?

Thank you for your quick reply,and understanding my question 🤔
Yes will have a smartphone. Our tour is at 10 AM, how long before it starts should we allow
to get inside.

You should pick up a good local map when you arrive. That will help a great deal. From where you are staying you should have no problems getting to the Vatican. Just cross the nearest bridge and head towards the Vatican wall. Keep the wall to your left and head towards the entrance near the rear. The crowds will pull you in the right direction.
Some folks prefer to forgo tours...they can be drudgery...too slow...the museum is well marked in English as are all of the other points of interest...your call. If you have a reservation (no tour) they tend to let you in when you arrive as long as you are not too early...the reservation will allow you to access the faster line.
To allow time for getting lost, from where you are allow an hour and expect to get there in 15 to 20 minutes if you don't get lost.

Thanks Mack ,great help.We are doing the official tour ,provided by Vatican.

You should pick up a good local map when you arrive.

Patty, I bought maps (nope, we don't use them on phones) before we left and marked locations of things we wanted to see. Yes, street names change every whipstitch and follow the loosest of grid patterns, if at all, but a good map will get you anywhere. Making your way on foot is also the most fun!

Looking at where you'll be staying, there are any number of reasonably direct routes to the Vatican. You could follow the river around and cross it at Ponte Vittorio Emanuele or Ponte Principe, or Corso Vittorio Emmanuele to Ponte Vittorio Emanuele, etc. Then head towards the Vatican, locate the wall that heads off to the north from Piazza San Pietro, and as Mack said, follow it around to the museum entrance.

I would get an early start so you don't really have to hustle. We all walk at different speeds, and then there are all those interesting things to stop and look at along the way.... Give yourself a little over an hour, maybe? It takes around 15 minutes to walk from Piazza San Pietro to the museums, if that gives you a reference for covering the rest of the distance. If in doubt, add some extra minutes: better to be a little to early than too late.

PS: aside from google maps on my laptop, I prefer old fashioned paper maps for sightseeing as it's easier to see larger areas on them for getting our bearings/choosing a route.

The residence is closer to the river than I would have guessed from the name. Not too far away is Largo Argentina with the Feltrinelli bookshop and the red awning. Just outside is the bus stop for the number 492 bus which if you don't want to walk will take you very close to the entry to the Vatican Museums.

It isn't the most frequent bus in the world, and the walk isn't bad, but your choice. I happen to like the 492 because of the route it takes.

I did a tour of the Vatican Museum and Sistine Chapel a few years ago with my wife and her mother and while they loved it it was drudgery to me. The museum is fascinating to say the least and takes you through a chronological history of the ancient times. If I see something that appeals to me I like to read the little placards next to it, and as such often found myself 20-30 feet behind the group and different than what the guide was describing in my ear. plus my TP's were constantly pulling on me to keep up. I likened it to walking down the crowded concourse after a sporting event here except everyone was speaking a different language. I am going back to Italy solo in three weeks and the last five days are in Rome. On the third day I have a reservation to go to the VM and SC armed with Rick's audio guide in my ear and no one telling me how fast I need to move.

As for your location, if you go to Google Maps and type in Campo de' Fiori Residence (it didn't recognize the street address) and the Vatican Museum you will find directions for a 34 minute walk to the Vatican, or a 15 minute taxi ride. There are no metro stops close to your lodging. If you're going to be there a while you might consider the hop on hop off buses, one if which stops at the Vatican and near all of the main sites. Have a great trip.

If you consider the hop-on hop-off buses look carefully at their routes and how close you get to what you want to see.

Because so much of Rome is pedestrianised and the rest in the Centro Storico has such narrow winding lanes the hop-on hop-off buses have tended to drop riders a fair distance from their goals.

Perhaps there are new routes that avoid those problems?

If you consider the hop-on hop-off buses...

My take on this? Skip the hohos in Rome. They've had mediocre to terrible reviews for a long time now, and you can often get from A to B faster on foot than waiting for a bus too overloaded to pick up passengers at the designated stops, can't get you right TO some of the attractions, and may have broken audio equipment and/or dirty vehicles. They work for some other cities but aren't a good method of getting about in Rome.

Thank you all for your help most appreciated.Will get a paper map.
I think we will walk.❤

I would get a taxi.

Although not a super long walk to the vatican, consider the fact that you will will be walking and standing for a long time at the Vatican, and you don't want to run out of steam during the tour. I would suggest either getting a taxi, or take Bus #23 which runs up Lungotevere dei Tebaldi, which is the road that runs along the river, and which should be less than a 5 minute walk to grab the bus. You can get off the bus at Piazza del Risorgimento, which is close to the entrance to the Vatican Museum (you didn't say if your tour is of the museum , but I assumed it was).