The best way, in my opinion, is a private car service. After a long flight, probably some jet lag, and not being familiar with the area, there is nothing better than having a private driver meet you inside the terminal and take you to your hotel. No fending off the so called independent cabs, waiting in the regular taxi line, or just having a "lost" feeling. It cost a little more, but not much. We can not say enough good things about Rome Cabs. It is a private car service despite the name. We always use them and have always been very pleased. Go to romecabs.com and see what you think. We just send an email and they answer us with a quote within 24 hours.