Ms Davis
My family and I find ourselves more comfortable in cars. Various autostrada routes are available. Midway towns down the spine of Italy are the likes of Sulmona, Avezzano, Foglia, which are the standard tourist style recommendations.
We prefer to look for farm stay types rather than inner city/town locations. Campobasso, Molise is worthy of consideration. So far rarely mentioned in the traditional guides which makes it attractive to me. Check it out on YouTube and perhaps https://lifeinitaly.com/campobasso/
Along the Adriatic Coast towns such as Pescara feature. Not my preference as most renaissance and baroque buildings in these towns were flatten in WW2 and replaced by brutalist modernistic concrete and brick square and rectangular buildings. Perhaps Vasto is the pick of a bad bunch. Depends on what you have been smoking.
To my eyes the beaches on the Ionian Sea on the inside of the heel are plain. (Actually, not an enthusiastic fan of any of the mainland Italian beaches.) If your normal surrounds are rural and sitting under an umbrella with a drink is your vision of beach life, you may have just found it. If, like me, California, Hawaiian, Australian rough and tumble surf beaches put a smile on your face, you may well be disappointed. I was.
I am taking a risk here. https://www.grottapalazzese.it/en/home/ is the masterpiece of Puglia dinning. Caveat. One must be comfortable and be able to resist gawking should internationally renowned barrister, and beautiful woman, Amal Alamuddin and her date show up, or perhaps King Federick of Denmark and his date, originally from Taroona Tasmania, Queen Mary, wander in. It is that sort of place.
Regards Ron