First trip to Europe

1) You have a lot of places listed with very few days dedicated to each one. This is an aggressive "first trip" itinerary because you'll be constantly moving from place to place and losing time with each move (transport time between each point and another, that is). I would cut down the number of places you're going to see - you'll have a more enjoyable and relaxing trip that way.

2) Paris seems like a real outlier, I would personally just stick to Italy. Three days in Paris is awfully short given its size (this applies to Rome and Tuscany as well).

3) Are your flights already set (arriving in Paris and departing in Milan?) or is it up in the air, no pun intended? If the latter, then the sequence should have some correlation with cost and convenience of flights from/to your hometown, wherever that is. Without knowing that, it's hard to advise as to where to start/end. I always pick places that are relatively less expensive to fly into and do open-jaw flights where it makes sense.

4) Did you calculate the distance between all these points, and determine travel mode and travel time between them? I assume you want to minimize travel time and cost, right? The itinerary looks like it has some zigzagging and backtracking. What about Venice-Vicenza-Milan-Cinque Terre-Florence-Tuscany-Rome instead? On a map that "appears" more straightforward but you'd have to check to be sure. By the way, Tuscany is a large region, so where in Tuscany?

It's your trip, but it is an awfully fast pace, especially for a first trip. It takes some time to orient yourself to Europe in general and to each new place you visit. Also, it is helpful to think in terms of nights in each location. You get 3 full days in Paris only if you spend 4 nights. If you are spending 3 nights, then it is only 2 full days to enjoy the sights. Your first day arriving from the U.S. is largely lost by the time you get through passport control, get to your hotel, unpack and shower, get oriented a bit, have a meal. About all you can do on Day 1 after arrival is take a nice walk.

Repeat this, to some extent, every time you change locations. Paris to Venice even by air will take 6 hours door-to-door what with airport transport, security, etc. So do you have 3 nights or 4 in Venice.

If you can clarify the number of nights you have in each location, I think we can help more. Paris and Rome are each worth, IMO, 5 nights each, minimum, and Venice a minimum of 3 nights. Milan is skippable on a first trip. If you are flying out of there, then maybe make it one night before flying.

I'd say take out at least 2 of those stops. Just keep repeating to yourself, "we'll be back, I don't have to fit everything in on this trip."

I agree that Paris should be a trip for another time. I love Vicenza and have stayed there but if you’re staying in Venice, I would not move to Vicenza for one night. There are frequent, inexpensive trains from Venice and the trip takes between 45 minutes and 1:15 depending on the train. Saves you a lot of time checking in and out of hotels, packing and unpacking. If you are not going to Paris, add a day to Florence, Tuscany and Rome.

On the premise that the destinations and number of days at each is set in stone, From Paris I would go to Rome and work my way north rather than the loop you have of Venice-Rome-Milan.

If you are looking for other 'advice', ask a new question.

My answer to your question is 'no'.

You are going to get to see lots of train stations with your schedule. That would be way too much for me and we've traveled to Europe for years. We did Rome, Venice, Florence, the train back to Rome on one trip. You could pack in the rest but Paris is just too much and too far, IMHO. Don't turn your vacation into a death march and convince yourself that you'll return, probably many times.

I agree with Phillip -- add more days to some of the destinations in Italy. You will return to Europe and can focus on Paris during another trip. Italy is a lovely country -- the Italians are genuinely warm and the food is amazing!